Drugs that have restrictions other than prior authorization, quantity limits, and action therapy affiliated with Every single prescription.
If coadministration of CYP3A4 inhibitors with fentanyl is important, check patients for respiratory depression and sedation at Repeated intervals and consider fentanyl dose changes right until stable drug effects are accomplished.
givinostat will raise the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
fedratinib will improve the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Change dose of drugs that happen to be CYP3A4 substrates as necessary.
Monitor Carefully (1)omaveloxolone will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Therapy could increase frequency of seizures in patients with seizure disorders and in other clinical options associated with seizures; observe patients for worsened seizure control during therapy
Prevent use when taking any oral drug which is depending on threshold concentrations for efficacy. Interactions listed are agent illustrations and don't involve all feasible clinical examples.
If concomitant use is unavoidable, maximize CYP3A substrate dosage in accordance with accredited product labeling.
fentanyl will lessen the level or effect of prasugrel by inhibition of GI absorption. Applies only to oral form of both of those agents. Modify Therapy/Check Carefully. Coadministration of opioid agonists hold off and lessen the absorption of prasugrel?
methylene blue and fentanyl equally raise serotonin levels. Stay away from or Use Alternate Drug. If drug combination need to be administered, monitor for evidence of serotonergic or opioid-related toxicities
After halting a CYP3A4 inducer, because the effects from the inducer drop, the fentanyl plasma concentration will increase which could increase or prolong the two the therapeutic and adverse effects.
If coadministration of CYP3A4 inhibitors with fentanyl is necessary, observe patients for respiratory depression and sedation at Repeated intervals and consider fentanyl dose adjustments till stable drug effects are obtained.
anastrozole will improve the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.
diazepam intranasal and fentanyl both equally maximize sedation. Stay away from or fentanyl iv adult dosage chart Use Alternate Drug. Restrict use to patients for whom different treatment options are insufficient